Product ID:V-01485 VERSED 1 ML
MSDS Date:05/13/1991
FSC:6505
NIIN:01-244-4736
MSDS Number: BXPBZ

HOFFMAN-LA ROCHE INC ROCHE LABORATORIES DIV

340 KINGSLAND ST
NUTLEY, NJ 07110-1199
US

Emergency Phone: 201-235-6660/800-526-6367

Info Phone: 800-526-1247/201-235-6660

Cage: 04493

ROCHE LABORATORIES, DIV. OF HOFFMANN-LA ROCHE INC.

NUTLEY, NJ 07110-1199 US

Telephone: 201-235-6660/800-526-6367

Cage: 66002

MIDAZOLAM HYDROCHLORIDE *95-1*

CAS: 59467-96-8

RTECS: NI2922250

BENZYL ALCOHOL

CAS: 100-51-6

RTECS: DN3150000

Fraction By Weight: 1 - 5%

HYDROCHLORIC ACID, HYDROGEN CHLORIDE, MURIATIC ACID

CAS: 7647-01-0

RTECS: MW4025000

Fraction By Weight: <1%

OSHA PEL 5 PPM

ACGIH TLV: 5 PPM

EPA Report Quantity: 5000 LBS

DOT Report Quantity: 5000 LBS

LD50 LC50 Mixture:ORAL LD50 (RAT): 1600 MG/KG MIDAZOLAM
Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EYES/SKIN: IRRITATION. BENZYL
ALCOHOL-CNS DEPRESSANT EFFECTS. MIDAZOLAM MALEATE-CNS DEPRESSANT
EFFECTS, IS TRANSPORTED ACROSS THE PLACENTA. VERSED PRODUCES
PHYSICAL DEPENDENCE & IS CLASSIFIED AS A CON TROLLED DANGEROUS
SUBSTANCE, SCHEDULE IV. (SEE SUPP)
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION. MIDAZOLAM MALEATE-DROWSINESS,
DIZZINESS, SEDATION, HYPNOSIS, TEMPORARY MEMORY LOSS, DECREASED
ANXIETY, MUSCLE RELAXATION, DIMINISHED REFLEXES, DECREASE IN
RESPIRATORY RATE, LACK OF MUSCLE COORDINATION, CONFUSION,
HEADACHE, DRY MOUTH, FATIGUE, NERVOUSNESS, NAUSEA, VOMITING,
HICCUPS.
Medical Cond Aggravated by Exposure:VERSED HYPERSENSITIVITY, ACUTE
NARROW ANGLE GLAUCOMA, LUNG/HEART/KIDNEY DISEASE.

First Aid:EYES: FLUSH W/PLENTY OF WATER. SKIN: FLUSH W/PLENTY OF WATER
& WASH CONTACT AREA W/SOAP & WATER. INHALATION: REMOVE TO FRESH
AIR. INGESTION: INDUCE VOMITING AS DIRECTED BY MEDICAL PERSONNEL.
NEVER GIV E ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. OBTAIN
MEDICAL ATTENTION IN ALL CASES.

Extinguishing Media:USE MEDIA APPROPRIATE FOR FIRE IN SURROUNDING
MATERIALS.
Fire Fighting Procedures:WEAR A SELF CONTAINED BREATHING APPARATUS. USE
WATER TO KEEP FIRE-EXPOSED CONTAINERS COOL.

Spill Release Procedures:WEAR PERSONAL PROTECTIVE EQUIPMENT & CLOTHING.
SAFELY SHUT OFF SOURCE OF LEAK. SMALL: MAY BE FLUSHED TO SANITARY
SEWER IF AVAILABLE. LARGE: DIKE & PUMP INTO METAL DRUMS/ABSORB
W/ABSORBENT MATERIAL. MO P/FLUSH AREA W/WATER TO SANITARY
SEWER.(SEE SUPP)

Handling and Storage Precautions:STORE AT ROOM TEMPERATURE, PROTECTED
FROM LIGHT, IN A SECURE STORAGE AREA IN COMPLIANCE W/FEDERAL
CONTROLLED SUBSTANCE ACT.
Other Precautions:AVOID CONTACT W/EYES & SKIN, CREATING MIST WHEN
HANDLING. WHEN HANDLING USE PROPER PERSONAL PROTECTIVE EQUIPMENT AS
NEEDED.

Respiratory Protection:WEAR A NIOSH APPROVED AIR-PURIFYING RESPIRATOR
EQUIPPED W/MIST FILTERS WHEN HANDLING BULK SOLUTIONS.
Ventilation:MECHANICAL (GENERAL): REQUIRED. LOCAL EXHAUST: SPECIFIC
VENTILATION REQUIRED FOR OPERATIONS GENERATING AIRBORNE MIST.
Protective Gloves:DISPOSABLE LATEX
Eye Protection:CHEMICAL GOGGLES FOR BULK SOLUTIONS
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
HEALTH HAZARDS CONT'D: CNS EFFECTS MAY BE INTENSIFIED &/PROLONGED BY
ALCOHOL, BARBITURATES/OTHER CNS DEPRESSANTS. RESULTS OF ALL AMES
TESTS WERE REPORTED TO BE NEGATIVE. SPILLS CONT'D: PUT SATURATED A
BSORBENT MATERIAL INTO A SUITABLE LABELED OPEN-HEAD DRUM. SECURE
DRUM COVER & MOVE CONTAINER TO A SAFE HOLDING AREA.

pH:3-4
Solubility in Water:COMPLETE
Appearance and Odor:COLORLESS TO LIGHT YELLOW CLEAR AQUEOUS SOLUTION.

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:LIGHT.
Hazardous Decomposition Products:FLUORINE, CHLORINE, NITROGEN OXIDES.

Waste Disposal Methods:DISPOSE OF WASTE IN A FEDERAL/STATE LICENSED
SECURE CHEMICAL LANDFILL/HAZARDOUS WASTE INCINERATOR IAW/FEDERAL,
STATE & LOCAL REGULATIONS.

======================================================================
Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.